Molecular Understanding of Osteoclast Differentiation and Physiology
نویسندگان
چکیده
منابع مشابه
Molecular Understanding of Osteoclast Differentiation and Physiology
Two types of cells, osteoblasts and osteoclasts, maintain bone homeostasis by balancing each other’s function [1,2]. Osteoblasts, which build bone, are derived from a mesenchymal progenitor cell that can also differentiate into marrow stromal cells and adipocytes [3]. Osteoclasts, originating from hemopoietic progenitors of the monocyte/macrophage lineage, immigrate into bone via the blood stre...
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Osteoclasts are bone-resorbing cells that are derived from hematopoietic precursor cells and require macrophage-colony stimulating factor and receptor activator of nuclear factor-κB ligand (RANKL) for their survival, proliferation, differentiation, and activation. The binding of RANKL to its receptor RANK triggers osteoclast precursors to differentiate into osteoclasts. This process depends on ...
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The osteoclast is the primary bone resorbing cell. It is a highly specialized multinucleated cell whose primary function is to help in the control of calcium homeostasis. The osteoclast has been very difficult to study because of its relative inaccessability, low numbers, and fragility when isolated from bone. Recently, techniques have been developed to study the cell biology of the osteoclast ...
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Osteoclasts, the bone resorbing cells, play a key role both in normal bone remodeling and in the skeletal osteopenia of arthritis, osteoporosis, periodontal disease and certain malignancies. Osteoclast cellular commitment, differentiation and function depend upon the establishment of specific patterns of gene expression achieved through networks of transcription factors activated by osteoclasto...
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Osteoclasts are multinucleated cells of hematopoietic origin that are responsible for the degradation of old bone matrix. Osteoclast differentiation and activity are controlled by two essential cytokines, macrophage colony-stimulating factor (M-CSF) and the receptor activator of nuclear factor-κB ligand (RANKL). M-CSF and RANKL bind to their respective receptors c-Fms and RANK to stimulate oste...
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ژورنال
عنوان ژورنال: Endocrinology and Metabolism
سال: 2010
ISSN: 2093-596X
DOI: 10.3803/enm.2010.25.4.264